The levels of CD4+CD25+ regulatory T cells in patients with allergic rhinitis

The involvement of CD4⁺CD25⁺ regulatory T cells (CD4⁺CD25⁺ T_Regs) in allergic diseases was reported previously. However, it remains unclear whether CD4⁺CD25⁺ T_Regs are involved in allergic rhinitis (AR).

Fresh whole blood from 20 patients with AR and 16 healthy donors was used to investigate the frequency of CD4⁺CD25⁺ and CD4⁺CD25^hi Treg cells using flow cytometry. In addition, serum total IgE (IU/mL) levels were determined using enzyme-linked immunosorbent assays.

Patients with AR had fewer CD4⁺CD25⁺ Treg cells (2.80 ± 1.36% vs. 3.94 ± 0.97%, P < 0.01) and CD4⁺CD25^hi T_Regs (1.53 ± 0·62% vs. 2.00 ± 0.52%, P < 0.05) than control subjects. The number of CD4⁺CD25⁺ and CD4⁺CD25^hi T_Regs was correlated negatively with total immunoglobulin E levels (r = -0.79, P < 0.01 and r = -0.61, P < 0.01, respectively).

Deficient regulatory T cells might play a role in the development of AR.