Related Experiment Video
Updated: Jan 2, 2026
Creation of Abdominal Adhesions in Mice
Published on: August 27, 2016
The effect of Allium sativum in experimental peritoneal adhesion model in rats
Uğur Topal1, Nuri Emrah Göret2, Ceren Canbey Göret3
1MD, Department of General Surgery, Erciyes University Medical Faculty, Melikgazi, Kayseri, Turkey. Conception and design of the study, statistics analysis, manuscript preparation and writing, final approval.
Purpose:
To evaluate the effect of garlic on formation of postoperative adhesions in rats.
Methods:
Twenty-four Sprague dawley rats were divided into three groups. In Group 1 (sham), laparotomy was performed and stitched up. In Group 2 (control), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and 2 cc of saline was intraperitoneally administered to each rat. In Group 3 (experimental), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and each rat was intraperitoneally administered a sterile Allium sativum derivative. The rats in all groups were re-laparotomized on postoperative day 7; samples were obtained from the peritoneal tissue surrounding the cecum.
Results:
In Group 3, there was a statistically significant difference in terms of inflammation, lymph node size, and free oxygen radicals; these parameters tended to increase. In terms of fibrosis evaluated using H&E and MT, there was no significant difference between groups 2 and 3.
Conclusions:
No positive outcomes indicating that Allium sativum reduces intra-abdominal adhesions were obtained. However, it caused severe inflammation in the tissue. Additionally, in immunohistochemical analyses conducted to detect oxidative stress, allium sativum increased the production of free oxygen radicals in the tissue.
