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Published on: April 28, 2023
Association between serum copper and heart failure: a meta-analysis
Lei Huang1, Ronghuan Shen2, Longfei Huang3
1Department of Cardiology, Ningbo Hangzhou Bay Hospital, Ningbo, China. huanglei6854@outlook.com.
Insights
This meta-analysis found that individuals with heart failure (HF) have significantly higher serum copper levels compared to healthy controls. These findings highlight a potential link between copper dyshomeostasis and heart failure development.
Area of Science:
- Biochemistry
- Cardiology
- Trace Elements
Background:
- Copper dysregulation is implicated in various diseases, including cardiovascular conditions.
- Conflicting evidence exists regarding the association between serum copper levels and heart failure (HF).
Purpose of the Study:
- To conduct a meta-analysis to clarify the relationship between serum copper levels and heart failure.
Main Methods:
- A systematic literature search was performed on PubMed and ScienceDirect databases up to June 2019.
- Included studies were analyzed using meta-analysis techniques to pool data on serum copper levels in HF patients and controls.
Main Results:
- Thirteen studies comprising 1504 participants were included.
- Patients with heart failure exhibited significantly higher serum copper levels than control subjects (SMD, 0.982; 95% CI, 0.679–1.285).
- Elevated serum copper was observed in heart failure patients across Asian and European populations, and in specific subtypes like ischemic cardiomyopathy and idiopathic dilated cardiomyopathy.
Conclusions:
- A significant association exists between elevated serum copper levels and heart failure.
- These findings suggest that serum copper may serve as a potential biomarker for heart failure.
Background And Objectives:
Copper dyshomeostasis can lead to many diseases, including cardiovascular disease. However, there are conflicting reports on the relationship between serum copper and heart failure (HF). To explore the relationship between serum copper levels and HF by performing a meta-analysis.
Methods And Study Design:
The PubMed and ScienceDirect databases until June 2019 were searched for reports on the association between serum copper levels and HF.
Results:
A total of thirteen studies including 1504 subjects were chosen for the meta-analysis. The pooled analysis indicated that patients with HF had higher serum copper than the control subjects [standardized mean difference (SMD), 0.982; 95% confidence interval (CI), (0.679, 1.285)]. Subgroup analysis stratified by different geographic locations found that HF patients had higher copper than the control subjects in Asia and Europe [Asia: SMD, 0.948 and 95% CI, (0.569, 1.327); Europe: SMD, 1.275 and 95% CI, (0.633, 1.917)], but not in America [America: SMD, 0.637 and 95% CI, (-0.109, 1.383)]. Additionally, subgroup analysis revealed that patients with ischemic cardiomyopathy (ICM) [SMD, 1.171; 95% CI, (0.717, 1.624)], idiopathic dilated cardiomyopathy (IDCM) [SMD, 0.569; 95% CI, (0.097, 1.042)] and other types of HF [SMD, 1.152; 95% CI, (0.594, 1.710)] all had higher copper levels than controls. Further subgroup analysis stratified by Newcastle-Ottawa Scale (NOS) scores also found higher serum copper in patients with HF than controls within each subgroup.
Conclusions:
Our meta-analysis identified a significant association between high serum copper and HF.
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