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Association between serum copper and heart failure: a meta-analysis
Lei Huang1, Ronghuan Shen2, Longfei Huang3
1Department of Cardiology, Ningbo Hangzhou Bay Hospital, Ningbo, China. huanglei6854@outlook.com.
Asia Pacific Journal of Clinical Nutrition
|December 12, 2019
Summary
This meta-analysis found that individuals with heart failure (HF) have significantly higher serum copper levels compared to healthy controls. These findings highlight a potential link between copper dyshomeostasis and heart failure development.
Area of Science:
- Biochemistry
- Cardiology
- Trace Elements
Background:
- Copper dysregulation is implicated in various diseases, including cardiovascular conditions.
- Conflicting evidence exists regarding the association between serum copper levels and heart failure (HF).
Purpose of the Study:
- To conduct a meta-analysis to clarify the relationship between serum copper levels and heart failure.
Main Methods:
- A systematic literature search was performed on PubMed and ScienceDirect databases up to June 2019.
- Included studies were analyzed using meta-analysis techniques to pool data on serum copper levels in HF patients and controls.
Main Results:
- Thirteen studies comprising 1504 participants were included.
- Patients with heart failure exhibited significantly higher serum copper levels than control subjects (SMD, 0.982; 95% CI, 0.679–1.285).
- Elevated serum copper was observed in heart failure patients across Asian and European populations, and in specific subtypes like ischemic cardiomyopathy and idiopathic dilated cardiomyopathy.
Conclusions:
- A significant association exists between elevated serum copper levels and heart failure.
- These findings suggest that serum copper may serve as a potential biomarker for heart failure.
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