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Exploring the Relation between Glottal Closure and Plasma Substance P: A Study Protocol.

Koichi Tsunoda1,2, Sho Hashimoto3, Hiroyuki Kuroda4

  • 1Department of Otolaryngology, National Hospital Organization Tokyo Medical Center.

The Tohoku Journal of Experimental Medicine
|December 13, 2019
PubMed
Summary
This summary is machine-generated.

This study investigates if substance P (SP) levels indicate glottal closure function in the elderly. Vocal exercises improved glottal closure and potentially increased SP, suggesting a link to better cough reflex and reduced aspiration pneumonia risk.

Keywords:
National Hospital Organization self-controlled vocal exerciseaspiration pneumoniaglottal closuremaximum phonation timesubstance P

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Area of Science:

  • Gerontology
  • Neurology
  • Speech-Language Pathology

Background:

  • Glottal incompetence, common in aging, impairs effective glottal closure.
  • Reduced substance P (SP) may correlate with increased aspiration pneumonia risk.
  • SP is vital for neuromuscular cough mechanisms.

Purpose of the Study:

  • To determine if blood substance P (SP) indicates glottal closure function in the elderly.
  • To investigate the effect of National Hospital Organization self-controlled vocal exercise (NHOEx) on SP levels.
  • To assess SP as a potential biomarker for aspiration pneumonia risk.

Main Methods:

  • 180 elderly patients (≥65 years) with dysphonia, dysphagia, or MPT < 15s.
  • 6-month treatment with NHOEx to improve glottal closure.
  • Measurement of plasma SP and Maximum Phonation Time (MPT) pre- and post-treatment.

Main Results:

  • NHOEx is hypothesized to improve glottal closure by strengthening laryngeal muscles.
  • Improved glottal closure and MPT are expected to correlate with increased plasma SP concentration.
  • This increase in SP would reflect an enhanced cough reflex.

Conclusions:

  • Plasma SP may serve as a reliable indicator of glottal closure and swallowing function.
  • SP measurement could aid in early detection of elderly individuals at high risk for aspiration pneumonia.
  • NHOEx shows promise in improving glottal function and potentially mitigating pneumonia risk.