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Association Between Ambient Air Pollution and Elevated Risk of Tuberculosis Development
Yi-Jun Lin1, Hsing-Chieh Lin2, Ying-Fei Yang2
1Institute of Food Safety and Health Risk Assessment, National Yang-Ming University, Taipei, Taiwan.
Infection and Drug Resistance
|December 13, 2019
Summary
Air pollution significantly increases tuberculosis (TB) risk, especially from carbon monoxide (CO), nitrogen oxides (NOx), and nitrogen dioxide (NO2). Reducing exposure to these pollutants can mitigate TB burden.
Area of Science:
- Environmental Health
- Epidemiology
- Public Health
Background:
- Global studies link ambient air pollution to tuberculosis (TB) development.
- The specific impact of air quality on TB risk in Taiwan remains unclear.
Purpose of the Study:
- To establish a population-level risk assessment for air pollution's contribution to TB.
- To evaluate TB risk associated with air quality across Taiwan's regions.
Main Methods:
- A Bayesian probabilistic risk assessment model was employed.
- Linked probabilistic air pollutant concentrations with epidemiological exposure-response models.
Main Results:
- Higher air pollution levels correlated with increased TB risk.
- Carbon monoxide (CO) showed the highest population attributable fraction (PAF), followed by nitrogen oxides (NOx) and nitrogen dioxide (NO2).
- CO, NOx, and NO2 exposures contributed significantly to TB development in high-pollution areas.
Conclusions:
- Findings support the link between poor air quality and TB risk.
- Reducing CO, NOx, and NO2 exposure is predicted to benefit individuals susceptible to TB.
- The developed approach can inform mitigation programs globally.
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