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Updated: Jan 2, 2026
Author Spotlight: In-Depth Morphometric Examination and Quantification of Native Lens Structure Using Whole Mount Imaging
Published on: January 19, 2024
Panoramic Observation of Crystalline Lenses with 25 MHz Ultrasonography
Wenwen Xue1, Haidong Zou1,2
1Department of Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai 200040, China.
Purpose:
To visualize and assess in vivo the age-related changes in crystalline lens size and contour.
Methods:
Seventy-nine healthy volunteers, 39 females and 40 males, with a mean age of 41.53 + 11.32 years (range: 21 to 60 years) were enrolled in this study. The axial lens thickness (ALT), equatorial lens diameter (ELD), and anterior (R a) and posterior (R p) lens surface radii of curvatures of the subjects' left eyes were measured with a 25 MHz ultrasound probe.
Results:
The mean ALT and ELD were 4.178 mm + 0.288 mm and 9.209 mm + 0.214 mm, respectively. There was a statistically significant increase in both ALT (slope = 11 μm/year, r = 0.88, p < 0.01) and ELD (slope = 6 μm/year, r = 0.60, p < 0.01) with age. R a negatively correlated, and R p did not change with age.
Conclusion:
There were no statistically significant relationships between any studied values and gender. Independent of gender, the lens grows equatorially and axially with age while its central anterior lens surface steepens and its posterior central surface curvature does not change.
