Bleeding control with calcium sulphate after oral surgery in anticoagulant therapy patients

Control of bleeding after oral surgery, is mandatory in patients taking anticoagulants. There are different haemostatic measure to prevent post-surgical bleeding. The aim of our study is to use a homeostatic agent, Calcium sulphate (P30, Ghimas, Bologna, Italy) for controlling post-surgical bleeding in a group of patients treated with warfarin therapy for thromboembolic states. Twenty teeth (12 mandibular molars, 8 maxillary molars) in 20 patients (14 men and 6 woman) with a mean age of 54.3 years (± 10.3 years) were included in the study. The patients were divided in 2 group; in 10 patients of the study group was used Calcium sulphate (P30, Ghimas, Bologna, Italy) in layers to fill the socket after extraction, while in control group was recommended to put a gauze with tranexamic acid in the extraction site immediately after extraction, and half an hour after extraction. The outcome was bleeding in subsequent days. Bleeding at post operative day 1 was significant in 5 patients of control group, otherwise in study group treated with calcium sulfate there was no bleeding in any patient (p. value 0.0055). CaS demonstrated to be a good hemostatic agent for controlling bleeding after oral surgery in patients taking anticoagulants.