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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Electrochemically Enabled Double C-H Activation of Amides: Chemoselective Synthesis of Polycyclic Isoquinolinones
Zi-Qiang Wang1, Cheng Hou1, Yuan-Fang Zhong1
1State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources , School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University , Guilin 541004 , People's Republic of China.
Abstract:
We developed an electrochemically enabled dehydrogenative annulation reaction of amides and alkynes for the synthesis of antitumor polycyclic isoquinolinones through a double C-H activation route. No external oxidant is required in this reaction, and electricity is used for Ru catalyst circulation. The most remarkable feature of this reaction is the effective improvement of product regioselectivity under mild electrolytic conditions in comparison with previously set strong oxidant conditions.
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