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2D-HELS MS Seq: A General LC-MS-Based Method for Direct and de novo Sequencing of RNA Mixtures with Different Nucleotide Modifications
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LC-MS quantification of oligonucleotides in biological matrices with SPE or hybridization extraction

Luc Sips1, Emmanuel Njumbe Ediage1, Benno Ingelse2

  • 1Development Bioanalysis, Janssen Research & Development, Beerse, Belgium.

Bioanalysis
|December 13, 2019
PubMed

Keywords:
anion-exchange extraction (AEX-SPE)antisense oligonucleotide (ASO)capture probe (CP)hybridization extractionsmall interfering RNA (siRNA)

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