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Tumor immune microenvironment modulation-based drug delivery strategies for cancer immunotherapy

Shuyan Han1, Keqing Huang, Zhipeng Gu

  • 1Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, PR China. wujun29@mail.sysu.edu.cn.

Nanoscale
|December 13, 2019
PubMed

Insights

Cancer immunotherapies show promise but face challenges. Modulating the tumor immune microenvironment (TIME) via advanced drug delivery offers a path to improve treatment efficacy and precision for better cancer immunotherapy outcomes.

Area of Science:

  • Oncology
  • Immunology
  • Drug Delivery Systems

Background:

  • Anti-cancer immunotherapies have shown clinical promise but are hindered by delivery issues, limited patient responses, and side effects.
  • The tumor immune microenvironment (TIME) plays a critical role in cancer development and response to therapy.

Purpose of the Study:

  • To review strategies for modulating the TIME to enhance cancer immunotherapy.
  • To summarize therapeutic principles and biotechniques for clinical translation of TIME-modulated cancer treatments.

Main Methods:

  • Comprehensive review of existing literature on TIME modulation in cancer immunotherapy.
  • Analysis of drug delivery systems and biotechniques for TIME modulation.
  • Discussion of recent advances and future prospects in the field.

Main Results:

  • TIME modulation strategies are significant for directing and improving cancer immunotherapy.
  • Versatile TIME modulation-based strategies, principles, and techniques are summarized.
  • Advances in drug delivery systems for TIME modulation are highlighted.

Conclusions:

  • Modulating the TIME is crucial for overcoming limitations in current cancer immunotherapies.
  • Advanced drug delivery systems hold promise for controlled and precise cancer immunotherapy.
  • Further research into TIME modulation-based delivery systems is essential for clinical transformation.

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