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Updated: Jan 2, 2026

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Published on: December 25, 2021
The hunt for radiation biomarkers: current situation
Gabriela Kultova1,2, Ales Tichy1, Helena Rehulkova1
1Department of Radiobiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
Developing rapid radiation biodosimetry methods is crucial for assessing exposure. This review highlights promising protein biomarkers in human plasma, like FDXR, for accurate dose assessment and epidemiological studies.
Area of Science:
- Radiation biology
- Biomarker discovery
- Molecular epidemiology
Background:
- Large-scale acute radiation exposure requires rapid dose assessment tools.
- Biomarkers are needed for molecular epidemiological studies correlating dose and health effects.
- Biological dosimetry focuses on identifying radiation-responsive biomarkers.
Purpose of the Study:
- To review current literature on radiation-responsive biomarkers for biological dosimetry.
- To summarize advances in radiation genomics, metabolomics, and proteomics.
- To identify candidate biomarkers for dose assessment.
Main Methods:
- Systematic literature review adhering to PRISMA guidelines.
- Analysis of radiation genomics, metabolomics, and proteomic studies.
- Focus on studies utilizing animal models and human patient data.
Main Results:
- Recent advances in omics approaches for radiation biodosimetry were described.
- Candidate biomarkers were identified across transcriptomic, metabolomic, and proteomic analyses.
- FDXR emerged as a promising transcriptomic and proteomic biomarker in human plasma.
Conclusions:
- Various methodological approaches and biological materials can predict radiation dose-effects.
- Protein biomarkers from human plasma are ideal for biodosimetry.
- FDXR is a highly promising biomarker, validated at both transcriptomic and protein levels in humans.
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