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Vancomycin-resistant gram-positive bacteria isolated from human sources.

K L Ruoff¹, D R Kuritzkes, J S Wolfson

¹Francis Blake Bacteriology Laboratories, Massachusetts General Hospital, Boston 02114.

Journal of Clinical Microbiology

|October 1, 1988

Summary

Vancomycin-resistant gram-positive bacteria, primarily Lactobacillus, Leuconostoc, and Pediococcus species, were identified in human samples. Some vancomycin-resistant lactobacilli from sterile sites were clinically significant, suggesting an emerging threat.

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Area of Science:

Microbiology
Infectious Diseases
Clinical Diagnostics

Background:

Reports of vancomycin-resistant gram-positive bacteria infections are increasing.
Understanding the diversity of these resistant bacteria is crucial for public health.
Identification of novel resistant strains necessitates further investigation.

Purpose of the Study:

To characterize vancomycin-resistant gram-positive bacterial isolates from human sources.
To identify the specific bacterial genera exhibiting vancomycin resistance.
To assess the clinical significance of these resistant isolates.

Main Methods:

Analysis of 36 vancomycin-resistant gram-positive isolates from clinical and stool samples.
Morphological and physiological testing for bacterial identification.

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Genus-level identification using standard microbiological techniques.

Main Results:

Twenty-five Lactobacillus, 6 Leuconostoc, and 3 Pediococcus species were identified.
Two isolates could not be assigned to a genus due to indeterminate morphology.
Four vancomycin-resistant Lactobacillus isolates from sterile sites were clinically significant.

Conclusions:

Vancomycin-resistant gram-positive bacteria, including Lactobacillus, Leuconostoc, and Pediococcus, are present in human samples.
These resistant organisms may represent an emerging class of nosocomial pathogens.
Improved laboratory methods are needed for accurate identification of these genera.