Inflammatory mediators and lung abnormalities in HIV: A systematic review
Breanne M Head1, Ruochen Mao1, Yoav Keynan1
1Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.
Plos One
|December 13, 2019
Summary
Inflammation markers are linked to lung damage in HIV patients. However, research on HIV and pneumonia co-infection is lacking, leaving gaps in understanding and treatment for lung dysfunction.
Area of Science:
- Immunology
- Pulmonology
- Infectious Diseases
Background:
- HIV and pneumonia infections impair lung function.
- Limited evidence exists on inflammation's role in co-infected individuals' lung dysfunction.
Purpose of the Study:
- Systematically review associations between inflammatory markers and lung abnormalities in HIV and pneumonia co-infected individuals.
- Identify gaps in current research.
Main Methods:
- Systematic review of 4 databases (PubMed, Cochrane, ClinicalTrials.gov, Google Scholar).
- Inclusion of adult studies reporting immune response and lung abnormality outcomes.
- Qualitative synthesis due to data heterogeneity.
Main Results:
- 7 studies met inclusion criteria; all focused on HIV, not HIV/pneumonia co-infection.
- Circulating biomarkers (IL-6, TNF-α, CRP, etc.) associated with lung abnormalities in HIV.
- No studies included patients with both HIV and pneumonia, or pneumonia alone.
Conclusions:
- Significant lack of research on inflammatory mediators' impact on lung function in HIV and pneumonia co-infected populations.
- Opportunities exist for developing anti-inflammatory treatments to prevent lung damage.
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