Related Experiment Video
Updated: Jan 2, 2026
08:27
Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
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Correction: Enhancing genomic selection by fitting large-effect SNPs as fixed effects and a genotype-by-environment
Plos One
|December 13, 2019
Summary
This study corrects a previous article DOI. The corrected DOI is 10.1371/journal.pone.0223898, ensuring proper citation and access to the research.
Area of Science:
- Correction of scientific literature references.
Context:
- Ensuring the accuracy of published scientific information is crucial for research integrity.
Purpose:
- To provide the correct Digital Object Identifier (DOI) for a specific scientific article.
Summary:
- This entry serves as a correction, updating the DOI for the article previously cited as 10.1371/journal.pone.0223898.
Impact:
- Facilitates accurate citation and retrieval of the scientific work, upholding scholarly communication standards.
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Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
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01:11Genome-wide Association Studies-GWAS
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
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02:46Genetic Screens
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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
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01:21Frequency-dependent Selection
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When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
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