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Ghrelin alterations during experimental and human sepsis.

I Nikitopoulou1, E Kampisiouli2, E Jahaj2

  • 1GP Livanos and M Simou Laboratories, 1st Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.

Cytokine
|December 13, 2019
PubMed
Summary

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Ghrelin levels, including active ghrelin, significantly increase during sepsis in both human patients and an experimental model. Higher active ghrelin levels correlate with better outcomes, suggesting a protective role in sepsis.

Area of Science:

  • Endocrinology
  • Immunology
  • Critical Care Medicine

Background:

  • Ghrelin, a gastric hormone, exhibits anti-inflammatory and immunomodulatory effects.
  • Sepsis is a life-threatening condition characterized by a dysregulated host response to infection.

Purpose of the Study:

  • To investigate ghrelin levels in patients experiencing sepsis.
  • To examine ghrelin levels in an experimental model of sepsis.

Main Methods:

  • Consecutive ICU admissions were screened; 34 patients who developed sepsis were enrolled.
  • Blood samples were collected at baseline and sepsis onset for hormone and cytokine analysis.
  • An experimental sepsis model using lipopolysaccharide (LPS) in mice was employed.

Main Results:

Keywords:
EndotoxemiaGhrelinLipopolysaccharideSepsis

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  • Serum total and active ghrelin concentrations were significantly elevated in septic patients compared to baseline.
  • Active ghrelin levels in sepsis inversely correlated with SOFA score and ICU length of stay.
  • In mice, LPS treatment increased ghrelin, leptin, TNFα, and IL-6; ghrelin administration reduced IL-6.

Conclusions:

  • Active and total ghrelin levels increase during sepsis in both clinical and experimental settings.
  • The inverse correlation of active ghrelin with severity scores suggests a potential protective role in sepsis.