Related Experiment Video

Updated: Jan 2, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

20.1K

Mineral Bone Abnormalities and Vascular Calcifications

Matthew Ray1, Anna Jovanovich2

  • 1Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.

Advances in Chronic Kidney Disease
|December 14, 2019
PubMed

Insights

Vascular calcification (VC) is common in chronic kidney disease (CKD). Mineral bone abnormalities in CKD contribute to the development and progression of VC, increasing mortality risk.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Mineral Metabolism

Background:

  • Vascular calcification (VC) is prevalent in chronic kidney disease (CKD), worsening with disease progression and strongly linked to mortality.
  • VC involves hydroxyapatite crystal deposition in arteries, resembling bone formation.
  • CKD disrupts mineral metabolism due to reduced glomerular filtration rate and altered levels of vitamin D, parathyroid hormone, and fibroblast growth factor 23.

Purpose of the Study:

  • To review the role of mineral bone abnormalities in CKD-related vascular calcification.
  • To explore the mechanisms linking disordered mineral metabolism to VC initiation and progression in kidney disease patients.

Main Methods:

  • Review of cell culture studies.
  • Analysis of animal models.
  • Examination of observational and clinical studies.

Main Results:

  • Abnormal mineral metabolism in CKD is implicated in VC.
  • Dysregulation of calcium and phosphorus metabolism is a key factor.
  • Evidence from multiple study types supports the link between mineral imbalances and VC.

Conclusions:

  • Mineral bone abnormalities are significant contributors to vascular calcification in CKD.
  • Understanding these mechanisms is crucial for managing VC in kidney disease.
  • Targeting mineral metabolism may offer therapeutic strategies for VC.

Keywords:
Chronic kidney Disease mineral bone disorderHyperphosphatemiaSecondary hyperparathyroidismVascular calcification

More Related Videos

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.3K
Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models09:01

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Published on: January 27, 2023

2.0K

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
5.8K
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.1K
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
433
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.4K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
5.6K