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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Bone-Vascular Axis in Chronic Kidney Disease.
Pieter Evenepoel1, Britt Opdebeeck2, Karel David1
1Department of Immunology and Microbiology, Laboratory of Nephrology and University Hospitals Leuven, KU Leuven - University of Leuven, Leuven, Belgium; Department of Nephrology and Renal Transplantation, University Hospital Gasthuisberg - Leuven, Leuven, Belgium.
Advances in Chronic Kidney Disease
|December 14, 2019
Summary
Chronic kidney disease (CKD) patients face a dual risk of osteoporosis and vascular calcification, a phenomenon known as the bone-vascular axis. Understanding this paradox may lead to treatments benefiting both bone and blood vessels.
Area of Science:
- Nephrology
- Endocrinology
- Vascular Biology
Background:
- Patients with chronic kidney disease (CKD) exhibit a higher incidence of osteoporosis and vascular calcification.
- The co-occurrence of bone demineralization and vascular mineralization in CKD is termed the 'calcification paradox' or 'bone-vascular axis'.
- This association is observed in both CKD patients and the general population, independent of aging.
Purpose of the Study:
- To review emerging concepts and key mechanisms underlying the bone-vascular axis in CKD.
- To explore the intricate relationship between bone metabolism and vascular calcification in CKD patients.
- To identify potential therapeutic targets for simultaneous bone and vascular health improvement in CKD.
Main Methods:
- Literature review focusing on the bone-vascular axis in chronic kidney disease.
- Analysis of common risk factors and underlying mechanisms linking bone and vascular pathology.
- Synthesis of current understanding regarding the bidirectional communication between bone and vasculature.
Main Results:
- Identified shared risk factors and mechanisms contributing to both bone and vascular disease in CKD.
- Highlighted the 'calcification paradox' where bone demineralization and vascular calcification coexist.
- Discussed potential pathways where calcifying vessels influence bone metabolism and vice versa.
Conclusions:
- The bone-vascular axis is a critical consideration in managing chronic kidney disease.
- A deeper comprehension of the mechanisms involved may reveal novel therapeutic strategies.
- Targeting the bone-vascular axis could offer simultaneous benefits for bone and vascular health in CKD patients.
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