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Leptin induces immunosenescence in human B cells
Daniela Frasca1, Alain Diaz1, Maria Romero1
1Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, USA.
Cellular Immunology
|December 14, 2019
Summary
Leptin induces inflammation in B cells from young lean individuals, making them resemble those from older or obese individuals. This suggests leptin may drive immunosenescence in human B cells.
Area of Science:
- Immunology
- Endocrinology
- Cell Biology
Background:
- Leptin, an adipokine, influences endocrine and immune functions.
- Leptin can increase pro-inflammatory cytokine secretion by immune cells.
Purpose of the Study:
- To investigate the effect of leptin on B cells from young lean individuals.
- To determine if leptin induces pro-inflammatory changes and immunosenescence markers in B cells.
Main Methods:
- Incubation of B cells from young lean individuals with leptin.
- Analysis of mRNA expression for pro-inflammatory cytokines, chemokines, micro-RNAs, TLR4, and p16.
- Assessment of B cell class switch and antibody production.
Main Results:
- Leptin increased pro-inflammatory B cells and induced intrinsic B cell inflammation.
- Upregulation of TNF-α, IL-6, IL-8, miR-155, miR-16, TLR4, and p16 observed.
- Leptin-treated B cells showed reduced class switch and influenza vaccine-specific IgG production.
Conclusions:
- Leptin induces a pro-inflammatory state and immunosenescence-like phenotype in B cells from young lean individuals.
- Leptin may contribute to immunosenescence in human B cells, mirroring changes seen in obese and elderly populations.
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