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Updated: Jan 2, 2026
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Novel 3,3-disubstituted oxindole derivatives. Synthesis and evaluation of the anti-proliferative activity
Michael S Christodoulou1, Ferdinando Nicoletti2, Katia Mangano2
1DISFARM, Sezione di Chimica Generale e Organica "A. Marchesini" Università degli Studi di Milano, via Venezian 21, 20133 Milano, Italy.
Abstract:
3,3-Disubstituted oxindole derivatives bearing a nitrogen atom at the C-3 position have been synthesized starting from 3-alkyl oxindole through a metal free pathway. These derivatives have been tested in five human tumor cell lines (PC3, MCF7, SW620, MiaPaca2 and A375) and on primary cells (PBMCs) from healthy donors providing compound 6d showing a strong anticancer effect in all cancer lines on the low micromolar range.
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