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Effects of Epstein-Barr virus infection on liver function in children

Yongju Zhang1, Yuqi Zhao1, Yajing Jiang1

  • 1Department of The Third Pediatrics, Cangzhou Central Hospital, No.16 XinHua Road, Cangzhou City, 061000, China.

Journal of Infection and Public Health
|December 14, 2019
PubMed

Insights

Epstein-Barr virus infection impacts children's liver function, particularly in toddlers during summer and autumn. The study suggests EBV affects liver health by influencing CD8+ T lymphocytes.

Area of Science:

  • Pediatric Infectious Diseases
  • Hepatology
  • Immunology

Background:

  • Epstein-Barr virus (EBV) is a common human herpesvirus.
  • EBV infection can manifest with various symptoms, including potential liver involvement in children.
  • Understanding the specific impact of EBV on pediatric liver function is crucial for timely diagnosis and management.

Purpose of the Study:

  • To investigate the effect of Epstein-Barr virus infection on liver function in children.
  • To identify age groups and seasons most susceptible to EBV infection in pediatric populations.
  • To analyze immunological and hematological changes associated with EBV-induced liver dysfunction.

Main Methods:

  • Comparative analysis of 118 EBV-infected children versus 10 healthy controls.
  • Assessment of blood cell counts, immune cell populations, and liver function indicators.
  • Analysis of EBV DNA expression, CD4+ and CD8+ T lymphocyte distribution, and granzyme B cell presence in liver tissue via immunohistochemistry and in situ hybridization.

Main Results:

  • Children aged 1-3 years in summer and autumn were most susceptible to EBV.
  • EBV infection led to increased Alanine transaminase (ALT), aspartate aminotransferase (AST), and other liver enzymes.
  • Elevated CD8+ T lymphocytes and increased IgG levels were observed, suggesting an immune response impacting the liver.

Conclusions:

  • Epstein-Barr virus infection significantly affects liver function in children.
  • The virus may exert its effects on the liver through the modulation of CD8+ T lymphocytes.
  • Early identification of susceptible age groups and seasons can aid in managing EBV-related pediatric liver issues.
Abstract

Keywords:
CD8+ T lymphocytesChildrenEB virusGranzyme B cellsLiver

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