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Precise Drug Delivery by Using PLGA-Based Microspheres and Optical Manipulators.

Hongbo Liu, Xiaojian Li, Tanyong Wei

    IEEE Transactions on Nanobioscience
    |December 14, 2019
    PubMed
    Summary

    This study introduces poly(lactide-co-glycolicacid) (PLGA)-based microspheres for precise in vivo drug delivery. These biocompatible microspheres enable targeted drug release and biodegradation, showing potential for drug testing and characterization.

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    Area of Science:

    • Biomedical Engineering
    • Materials Science
    • Pharmacology

    Background:

    • Precise drug delivery is critical for effective clinical applications.
    • Controlling drug amount and location is essential for successful therapeutic outcomes.
    • Existing drug delivery methods may lack the required precision for specific applications.

    Purpose of the Study:

    • To develop and evaluate a novel drug delivery system using poly(lactide-co-glycolicacid) (PLGA)-based microspheres.
    • To demonstrate the precise in vivo delivery and controlled release of drugs using optical tweezer manipulation.
    • To assess the biocompatibility and biodegradation of PLGA microspheres in a zebrafish model.

    Main Methods:

    • Fabrication of PLGA-based microspheres loaded with drugs.

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  • Utilizing optical tweezers for targeted in vivo delivery of microspheres to zebrafish embryos.
  • Monitoring drug release and evaluating biological effects (angiogenesis/anti-angiogenesis).
  • Assessing microsphere degradation and biocompatibility in vivo.

    • Main Results:

    • PLGA microspheres successfully delivered precise drug amounts to targeted sites in vivo.
    • Sustained drug release from microspheres was observed in zebrafish embryos.
    • PLGA microspheres demonstrated good biocompatibility and biodegradation within the zebrafish model.
    • The system showed potential for examining angiogenesis and anti-angiogenesis activities.

    Conclusions:

    • PLGA-based microspheres combined with optical tweezers offer a precise and biocompatible in vivo drug delivery method.
    • This approach facilitates controlled drug release and is suitable for studying biological processes like angiogenesis.
    • The system holds promise for applications in protein testing and in vivo drug property characterization.