Related Experiment Video
Updated: Jan 2, 2026
16:17
The ITS2 Database
Published on: March 12, 2012
32.2K
AcetoBase: a functional gene repository and database for formyltetrahydrofolate synthetase sequences
Abhijeet Singh1, Bettina Müller1, Hans-Henrik Fuxelius1
1Department of Molecular Sciences, Swedish University of Agricultural Sciences, Uppsala BioCenter, Box 7025, SE-750 07 Uppsala, Sweden.
Database : the Journal of Biological Databases and Curation
|December 14, 2019
Summary
AcetoBase is a new database for formyltetrahydrofolate synthetase (FTHFS) sequences from acetogenic bacteria. This resource aids in the taxonomic study and identification of these crucial microbes involved in carbon cycling.
Area of Science:
- Microbiology
- Environmental Science
- Biotechnology
Background:
- Acetogenic bacteria are vital for carbon cycling and biotechnology.
- Their diversity complicates systematic taxonomic studies.
- The Wood-Ljungdahl pathway (WLP) is central to acetogen metabolism.
Purpose of the Study:
- To develop a centralized repository for formyltetrahydrofolate synthetase (FTHFS) gene sequences.
- To facilitate systematic taxonomic studies of acetogenic bacteria.
- To provide a tool for identifying acetogens using molecular markers.
Main Methods:
- Systematic collection and organization of FTHFS sequence data (nucleotide and protein).
- Development of AcetoBase, a dedicated database and repository.
- Implementation of homology search and BLAST functionalities within the database.
Main Results:
- AcetoBase provides a comprehensive collection of FTHFS sequences.
- The database enables sequence identification and homology searches.
- It offers metadata for genome content and WLP information.
Conclusions:
- AcetoBase streamlines research on acetogenic bacteria.
- It serves as a valuable tool for identifying potential acetogens.
- The database supports studies on microbial communities and carbon cycling.
More Related Videos
Related Concept Videos
02:47Protein Families
16.5K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key...
16.5K
01:29Modern Molecular Taxonomy
519
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
519
02:02Cis-regulatory Sequences
3.9K
3.9K
02:02Cis-regulatory Sequences
11.5K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.5K
02:19Export of Mitochondrial and Chloroplast Genes
4.1K
A eukaryotic cell can have up to three different types of genetic systems: nuclear, mitochondrial, and chloroplast. During evolution, organelles have exported many genes to the nucleus; this transfer is still ongoing in some plant species. Approximately 18% of the Arabidopsis thaliana nuclear genome is thought to be derived from the chloroplast’s cyanobacterial ancestor, and around 75% of the yeast genome derived from the mitochondria’s bacterial ancestor. This export has occurred...
4.1K
01:57Gene Families
9.7K
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
9.7K