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Long term thyroid function after subtotal thyroidectomy for Graves' disease.

B Busnardo1, M E Girelli, D Rubello

  • 1Istituto di Semeiotica Medica, Università di Padova, Italy.

Journal of Endocrinological Investigation
|May 1, 1988
PubMed
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Subtotal thyroidectomy for Graves

Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Thyroidology

Background:

  • Graves' disease is an autoimmune disorder leading to hyperthyroidism.
  • Subtotal thyroidectomy is a common surgical treatment for Graves' disease.
  • Long-term thyroid function and recurrence rates after surgery require careful evaluation.

Purpose of the Study:

  • To assess the long-term outcomes of subtotal thyroidectomy in Graves' disease patients.
  • To evaluate thyroid function, recurrence rates, and complications following surgery.
  • To identify factors influencing post-operative thyroid status.

Main Methods:

  • A cohort of 93 Graves' disease patients underwent subtotal thyroidectomy with a standardized thyroid remnant size.
  • Thyroid function was monitored for up to 6 years post-surgery.

Related Experiment Videos

  • Patient demographics, antibody titers, and lymphocytic infiltration were analyzed for correlations.

    • Main Results:

    • No operative mortality or major complications occurred.
    • Post-operative hypothyroidism (overt and subclinical) was common, with variations over time.
    • Recurrence of hyperthyroidism occurred in 3-4% of patients, primarily in younger females.
    • Younger patients (<20 years) had a higher incidence of hypothyroidism.
    • High TMA titers were associated with relapses.

    Conclusions:

    • Subtotal thyroidectomy is a safe procedure for Graves' disease with low complication rates.
    • Long-term thyroid function monitoring is crucial due to the high incidence of hypothyroidism and potential for recurrence.
    • Age and antibody titers may influence post-operative outcomes.