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Association between pioglitazone use and head and neck cancer: Population-based case-control study
Tzong-Hann Yang1,2,3, Sudha Xirasagar4, Yen-Fu Cheng2,5,6,7
1Department of Otorhinolaryngology, Taipei City Hospital, Taipei, Taiwan.
Background:
This study aimed to evaluate the association between pioglitazone use and the occurrence of head and neck cancer.
Methods:
Data for this case-control study were retrieved from the Taiwan National Health Insurance Research Database. A total of 21 464 diabetic patients newly diagnosed with head and neck cancers were identified. We used propensity score matching to select 64 392 comparison patients (3:1 ratio). Multiple logistic regression modeling was used to examine the association of head and neck cancer with pioglitazone use in the 5 years preceding the cancer diagnosis.
Results:
Bivariate analysis showed a significant difference in the prevalence of prior using pioglitazone between cases and controls (19.3% vs 18.5%, P < .001) was observed. Multiple regression analysis showed adjusted odds of pioglitazone use of 1.06 (95% CI: 1.02-1.10) among cases relative to controls.
Conclusions:
Prior pioglitazone use was associated with oral cavity cancer.
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