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Related Experiment Video

Updated: Jan 2, 2026

Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples
08:49

Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples

Published on: January 13, 2023

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Liquid biopsy.

V Candotto1, F Pezzetti2, A Scarano3

  • 1Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

Journal of Biological Regulators and Homeostatic Agents
|December 14, 2019
PubMed
Summary
This summary is machine-generated.

Analyzing circulating tumor cells (CTCs) and circulating nucleic acids offers a non-invasive method for cancer diagnosis and therapy selection. These biomarkers provide insights into tumor evolution and treatment response.

Keywords:
DNAbloodcirculating tumor cellsliquid biopsytumor

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biomedical Engineering

Background:

  • Circulating tumor cells (CTCs) shed from primary tumors into the bloodstream during early cancer development.
  • Current cancer therapies often rely on tissue biopsies, which can be invasive and may not reflect tumor heterogeneity or resistance.
  • Metastatic cells can possess distinct characteristics compared to primary tumor cells, impacting treatment strategies.

Conclusions:

  • Circulating tumor cells and circulating nucleic acids serve as valuable tools for companion diagnostics in oncology.
  • Analysis of CTCs and CNAs can enhance patient stratification for targeted therapies.
  • These approaches provide insights into the dynamic selection of cancer cells under therapeutic pressure.