Albanitriles A-G: Antiprotozoal Polyacetylene Nitriles from a Mycale Marine Sponge
Samuele Sala1, Jane Fromont2, Oliver Gomez2
1School of Molecular Sciences , The University of Western Australia , Crawley , WA 6009 , Australia.
Abstract:
Seven new nitrile-bearing polyacetylenes, named albanitriles A-G, were isolated from a marine sponge of the Mycale genus (Order: Poecilosclerida, Family: Mycalidae) collected near Albany, Western Australia. Structural elucidation was achieved using a combination of high-resolution mass spectrometry and ultraviolet/visible, infrared, and nuclear magnetic resonance spectroscopy. The compounds were found to possess moderate activity against Giardia duodenalis when compared to a metronidazole positive control.
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