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An efficient strategy for circulating tumor cell detection: surface-enhanced Raman spectroscopy.

Jie Lin1, Jianping Zheng, Aiguo Wu

  • 1Cixi Institute of Biomedical Engineering, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, 1219 ZhongGuan West Road, Ningbo, 315201, China. aiguo@nimte.ac.cn Zhengjianping@nimte.ac.cn.

Journal of Materials Chemistry. B
|December 14, 2019
PubMed
Summary

Detecting circulating tumor cells (CTCs) is crucial for cancer management. Surface-enhanced Raman scattering (SERS) offers a highly sensitive, label-free method for CTC detection, showing great promise for clinical applications.

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Area of Science:

  • Biotechnology
  • Analytical Chemistry
  • Oncology

Background:

  • Circulating tumor cells (CTCs) are key drivers of cancer metastasis and patient mortality.
  • Early and accurate detection of CTCs is vital for effective cancer diagnosis, treatment monitoring, and prognosis.

Purpose of the Study:

  • To provide an overview of Surface-Enhanced Raman Scattering (SERS) biosensing substrates for detecting circulating tumor cells (CTCs).
  • To highlight recent advancements in high-sensitivity SERS platforms for CTC analysis.
  • To offer insights into designing and applying high-performance SERS platforms, particularly those using non-metal materials, for CTC detection.

Main Methods:

  • Review of Surface-Enhanced Raman Scattering (SERS) technology and its application as a bioprobe.
  • Analysis of recent achievements in SERS-based platforms for detecting circulating tumor cells (CTCs).
  • Focus on the development and utilization of non-metal materials in SERS platforms for enhanced CTC detection.

Main Results:

  • SERS exhibits remarkable sensitivity, non-destructive analysis, label-free detection, rapid response, and molecular fingerprinting capabilities.
  • SERS technology has demonstrated significant potential and increasing application in detecting and analyzing biological components, including CTCs.
  • High-sensitivity SERS platforms, especially those incorporating non-metal materials, show promise for advanced CTC detection.

Conclusions:

  • SERS is a powerful technique with unique advantages for the sensitive and specific detection of circulating tumor cells (CTCs).
  • Continued development of SERS biosensing substrates and platforms, particularly using innovative non-metal materials, is crucial for advancing CTC detection and improving cancer patient outcomes.