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The Use of an Autologous Cell Harvesting and Processing Device to Decrease Surgical Procedures and Expedite Healing
Autumn D Nanassy1, Paul M Glat1, Brooke A Burkey1
1St. Christopher's Hospital for Children, Philadelphia, PA.
Wounds : a Compendium of Clinical Research and Practice
|December 14, 2019
Summary
Autologous cell suspension (ACS) combined with split-thickness skin grafts (STSGs) shows promise in pediatric burn care, potentially reducing surgeries and speeding up healing for extensive burns.
Area of Science:
- Regenerative Medicine
- Pediatric Burn Surgery
Background:
- Autologous cell harvesting devices enable rapid preparation of non-cultured autologous cell suspension (ACS).
- ACS is designed for immediate topical application to wound areas post-enzymatic and physical disruption.
Observation:
- Two pediatric patients with extensive partial- and full-thickness burns were treated with ACS and split-thickness skin grafts (STSGs).
- Patient 1: 4-year-old female with 32% total body surface area (TBSA) burns, discharged 19 days post-treatment.
- Patient 2: 18-month-old female with 21% TBSA burns, discharged 22 days post-treatment with meshed autograft.
Findings:
- Neither patient required additional surgical interventions.
- All treated and donor sites remained infection-free.
- No unexpected treatment-related adverse events were reported for either patient.
Implications:
- This case report is the first to describe ACS with STSGs in pediatric burn patients.
- The findings suggest ACS can decrease surgical procedures and expedite healing in pediatric patients with large surface burns.
- This approach may offer a novel adjunct for definitive closure of severe burn injuries and donor sites.
