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Related Experiment Videos

Rabies presenting with myocarditis and encephalitis.

G V Raman1, A Prosser, P L Spreadbury

  • 1St Mary's Hospital, Portsmouth, U.K.

The Journal of Infection
|September 1, 1988
PubMed
Summary

This case study details a 45-year-old woman in Zambia diagnosed with rabies after initial influenza-like symptoms. Rabies diagnosis was confirmed by hydrophobia, leading to fatal brain death.

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Cardiology

Background:

  • Rabies is a fatal viral zoonotic disease transmitted through infected animal bites.
  • Early symptoms can be non-specific, mimicking other viral infections, delaying diagnosis.

Observation:

  • A 45-year-old woman presented with influenza-like illness and myocarditis, later developing hydrophobia consistent with rabies.
  • The patient required mechanical ventilation and heavy sedation due to neurological deterioration.
  • Syndrome of inappropriate antidiuretic hormone secretion (SIADH) complicated the clinical course.

Findings:

  • The patient rapidly progressed to rabies encephalitis despite supportive care.
  • Myocarditis and fever resolved, but neurological decline continued.

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  • Brain death was diagnosed 14 days after admission.

    • Implications:

    • This case highlights the importance of considering rabies in patients with unexplained neurological and systemic symptoms, especially in endemic areas.
    • The presentation underscores the rapid progression and poor prognosis of rabies.
    • Early recognition and intervention, though challenging, are critical for rabies management.