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Updated: Jan 2, 2026

The Polyvinyl Alcohol Sponge Model Implantation
Published on: April 18, 2012
New cytotoxic polyacetylene alcohols from the Egyptian marine sponge Siphonochalina siphonella
Dae-Won Ki1, Ahmed H El-Desoky2,3, Chin Piow Wong1
1Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.
Abstract:
Three new polyacetylenic alcohols, siphonellanols A-C (1-3), together with two known polyacetylenic alcohols (4-5), were isolated from the CHCl3-soluble fraction of the methanolic extract of the marine sponge Siphonochalina siphonella, collected in Egypt. The structures of 1-3 were determined by spectroscopic analyses of their 1D-, 2D-NMR, and MS spectra and by comparisons with reported data. The cytotoxicity assay revealed that 1-3 exhibited moderate cytotoxic activities against a human cervical cancer cell line (HeLa), a human breast cancer cell line (MCF-7), and a human lung cancer cell line (A549) with IC50 values ranging from 25.9 to 69.2 μM.
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