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Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Nitroxoline: repurposing its antimicrobial to antitumor application.

Ana Mitrović¹, Janko Kos²

¹Department of Biotechnology, Jožef Stefan Institute, 1000 Ljubljana, Slovenia.

Acta Biochimica Polonica

|December 14, 2019

Summary

Nitroxoline, an antimicrobial drug, shows promise for cancer treatment. Repurposing nitroxoline offers a cost-effective strategy to develop new cancer therapies, improving patient outcomes and reducing healthcare burdens.

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Area of Science:

Oncology
Drug Repurposing
Antimicrobial Agents

Background:

Cancer remains a leading cause of death and a significant burden on healthcare systems worldwide.
Developing novel cancer therapeutics is hindered by high costs and lengthy evaluation processes.
Drug repurposing, particularly in oncology, offers a viable strategy to accelerate the availability of new treatments.

Purpose of the Study:

To review the molecular mechanisms and tumor models demonstrating nitroxoline's efficacy in impairing tumor progression.
To explore the potential of nitroxoline as a repurposed drug for cancer treatment.
To assess the development of nitroxoline derivatives for enhanced anticancer potency and selectivity.

Main Methods:

Literature review of studies investigating nitroxoline's role in cancer.
Analysis of molecular mechanisms underlying nitroxoline's antitumor activity.
Examination of structure-based chemical synthesis of nitroxoline derivatives.

Main Results:

Nitroxoline has demonstrated potent antitumor activity across various molecular mechanisms and tumor models.
Studies indicate nitroxoline's effectiveness in impairing tumor progression.
Chemical synthesis efforts are underway to create more potent and selective nitroxoline derivatives.

Conclusions:

Nitroxoline is a promising candidate for repurposing as an anticancer agent.
Repurposing nitroxoline presents significant benefits for cancer patients and healthcare systems.
Further development of nitroxoline and its derivatives could lead to improved cancer therapies.