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08:14
A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
Published on: August 28, 2018
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Circulating PCSK9 levels are not associated with the conversion to type 2 diabetes
Stéphane Ramin-Mangata1, Matthieu Wargny2, Matthieu Pichelin3
1Université La Réunion, Inserm UMR 1188 DéTROI, Sainte Clotilde, France.
Atherosclerosis
|December 14, 2019
Summary
This study found no significant link between plasma PCSK9 levels and new-onset diabetes (NOD) risk. These findings suggest that inhibiting PCSK9 may not negatively impact glucose homeostasis.
Area of Science:
- Cardiovascular Research
- Metabolic Disorders
- Biochemistry
Background:
- Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of LDL receptor metabolism.
- Recent studies have questioned the potential diabetogenic risk associated with PCSK9 inhibitors.
Purpose of the Study:
- To investigate the association between plasma PCSK9 levels and the risk of new-onset diabetes (NOD).
Main Methods:
- Analysis of plasma PCSK9 levels using ELISA in two prospective cohorts (IT-DIAB and ELSA-Brasil).
- Longitudinal assessment of NOD incidence using multivariable Cox models.
- Exploration of associations with glucose homeostasis parameters and HOMA-IR.
Main Results:
- Plasma PCSK9 levels showed no significant association with NOD in either cohort.
- A positive association was observed between PCSK9 levels and worsening glucose homeostasis, including progression to prediabetes, in the ELSA-Brasil cohort.
- PCSK9 levels correlated positively with fasting plasma glucose changes and HOMA-IR in ELSA-Brasil.
Conclusions:
- Plasma PCSK9 levels are not significantly associated with the risk of developing new-onset diabetes.
- Inhibition of the PCSK9 pathway is unlikely to be detrimental to glucose homeostasis.
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