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Platelet-to-lymphocyte ratio is associated with cardiovascular disease in continuous ambulatory peritoneal dialysis

Tianlei Chen1, Min Yang1

  • 1Department of Nephrology, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, PR China.

International Immunopharmacology
|December 14, 2019
PubMed

Insights

High platelet-to-lymphocyte ratio (PLR) is a significant predictor of cardiovascular disease (CVD) events in continuous ambulatory peritoneal dialysis (CAPD) patients. This simple test can help identify patients at higher risk for CVD events.

Area of Science:

  • Nephrology
  • Cardiology
  • Inflammation Biomarkers

Background:

  • Patients with chronic kidney disease (CKD) exhibit elevated cardiovascular disease (CVD) risk, often linked to systemic inflammation.
  • Platelet-to-lymphocyte ratio (PLR) is an emerging inflammatory marker.
  • The inflammatory status in continuous ambulatory peritoneal dialysis (CAPD) patients is a key factor in CVD development.

Purpose of the Study:

  • To investigate the association between PLR and the incidence of CVD events in CAPD patients.
  • To determine if PLR can serve as a predictive marker for CVD events in this population.

Main Methods:

  • A cohort of 70 stable CAPD patients was monitored from February 2014 to March 2017.
  • Demographic and baseline clinical laboratory data were collected.
  • Binary logistic regression analysis was employed to assess the relationship between PLR and CVD events.

Main Results:

  • During a median follow-up of 22 months, 40% of CAPD patients experienced CVD events.
  • Patients with CVD events showed significantly higher platelets, C-reactive protein, PLR, and neutrophil-to-lymphocyte ratio (NLR).
  • High PLR was identified as an independent predictor of CVD events (OR, 1.05; 95% CI, 1.02-1.08; p<0.01), whereas high NLR was not.

Conclusions:

  • PLR is independently associated with CVD events in CAPD patients.
  • Elevated PLR can predict the risk of CVD events.
  • PLR is an easily obtainable and potentially routine clinical test for risk assessment.
Abstract

Keywords:
Cardiovascular diseaseContinuous ambulatory peritoneal dialysisNeutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratio

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