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Updated: Jan 2, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms
Consuelo Pitolli1,2, Ying Wang3, Eleonora Candi1,4
1Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133 Roma, Italy.
None:
The tumor suppressor p53 regulates different cellular pathways involved in cell survival, DNA repair, apoptosis, and senescence. However, according to an increasing number of studies, the p53-mediated canonical DNA damage response is dispensable for tumor suppression. p53 is involved in mechanisms regulating many other cellular processes, including metabolism, autophagy, and cell migration and invasion, and these pathways might crucially contribute to its tumor suppressor function. In this review we summarize the canonical and non-canonical functions of p53 in an attempt to provide an overview of the potentially crucial aspects related to its tumor suppressor activity.
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