Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Olive Mill Wastewater-Loaded Polysaccharide Hydrogels as Potential Antibacterial Films for Wound Healing.

Gels (Basel, Switzerland)·2026
Same author

Correction: Regulatory actions of LH and follicle-stimulating hormone on breast cancer cells and mammary tumors in rats.

Frontiers in endocrinology·2026
Same author

Cellulose-Based Hydrogels Incorporating Olive Mill Wastewater (OMW): Preparation, Characterization, and In Vitro Antimicrobial Activity.

Gels (Basel, Switzerland)·2026
Same author

Exploring the Hydrazone Group in Multifunctional Approaches for Alzheimer's Disease Therapy.

ChemMedChem·2026
Same author

Safety and efficacy of transcatheter aortic valve replacement for native pure aortic valve regurgitation.

Journal of cardiovascular medicine (Hagerstown, Md.)·2026
Same author

Decoupling simultaneous motor imagination and execution via orthogonal ECoG neural representations.

Nature communications·2026

Related Experiment Video

Updated: Jan 1, 2026

Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification
07:32

Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification

Published on: April 7, 2017

9.9K

Poloxamer Hydrogels for Biomedical Applications.

Eleonora Russo1, Carla Villa1

  • 1Department of Pharmacy, University of Genoa, Viale Benedetto XV, 16132 Genova, Italy.

Pharmaceutics
|December 15, 2019
PubMed
Summary

Thermoresponsive poloxamer hydrogels are fluid at room temperature and gel at body temperature, offering prolonged drug delivery. These versatile PEO-PPO-PEO copolymers also find use in tissue engineering and as biosurfactants.

Keywords:
biomedicalcopolymerhydrogelsmicellepoloxamerthermosensitive

More Related Videos

A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
08:59

A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies

Published on: January 14, 2020

18.8K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.6K

Related Experiment Videos

Last Updated: Jan 1, 2026

Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification
07:32

Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification

Published on: April 7, 2017

9.9K
A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
08:59

A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies

Published on: January 14, 2020

18.8K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.6K

Area of Science:

  • Polymer Science and Biomaterials

Background:

  • Poloxamers are synthetic triblock copolymers (poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)), known commercially as Pluronics®, Synperonics®, or Lutrol®.
  • These copolymers exhibit thermoresponsive behavior, forming hydrogels that transition from liquid to gel with increasing temperature.

Purpose of the Study:

  • To review the biomedical applications of poloxamer-based thermoresponsive hydrogels.
  • To explore their utility in drug delivery systems and tissue engineering.
  • To evaluate the role of poloxamers as biosurfactants.

Main Methods:

  • Review of literature on poloxamer hydrogels and their properties.
  • Analysis of poloxamer structure-property relationships (molecular weight, PEO:PPO ratio).
  • Discussion of critical micelle concentration (CMC) and micelle formation.

Main Results:

  • Poloxamer hydrogels are fluid at room temperature and gel at body temperature, enabling sustained drug release.
  • Various poloxamer formulations exist, ranging from liquids to solids, with tunable properties.
  • Poloxamers act as effective biosurfactants, forming micelles utilized in drug delivery.

Conclusions:

  • Thermoresponsive poloxamer hydrogels are highly promising for ophthalmic, injectable, transdermal, and vaginal drug delivery.
  • Their thermoreversible gelling and biosurfactant properties make them versatile for advanced biomedical applications, including tissue engineering.