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A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
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A Microfluidic Detection System for Bladder Cancer Tumor Cells.

Shuxing Lv1, Jinwei Yu1, Yan Zhao2

  • 1School of Medical Laboratory, Tianjin Medical University, Tianjin 300203, China.

Micromachines
|December 15, 2019
PubMed
Summary

A novel microfluidic chip effectively detects bladder cancer cells in urine, overcoming interference from other cells. This technology offers a promising new tool for early bladder cancer diagnosis.

Keywords:
bladder cancercell image recognitiondetection systemsmicrofluidicstumor cell detection

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Area of Science:

  • Biomedical Engineering
  • Oncology
  • Analytical Chemistry

Background:

  • Excreted tumor cells in urine aid bladder cancer diagnosis.
  • Urinary white blood cells and epithelial cells hinder tumor cell identification.

Purpose of the Study:

  • To develop and evaluate a microfluidic system for detecting bladder cancer cells in urine.
  • To assess the system's practicality and efficiency in a clinical diagnostic context.

Main Methods:

  • Utilized a microfluidic cell chip for detecting bladder cancer cells (T24) and non-tumor cells (MeT-5A).
  • Analyzed tumor cell concentrations ranging from 1 × 10⁴ to 300 × 10⁴ cells/mL.
  • Evaluated detection rates and stability using phosphate buffer saline (PBS) and urine as diluents.

Main Results:

  • Achieved tumor cell detection rates of 63-71% in PBS and 64-72% in urine.
  • Demonstrated high detection stability with coefficient of variation (CV%) between 3.9-6.7%.
  • Reported an overall bladder cancer cell recognition rate of 68.4% at a speed of 2 mL/h.

Conclusions:

  • Microfluidic analysis chip technology provides a viable method for detecting bladder cancer cells in urine.
  • The developed system shows potential for improving bladder cancer diagnosis through non-invasive urine analysis.