Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

780
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
780
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

13.9K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
13.9K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.8K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.8K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.8K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.8K
Blood Transfusion01:15

Blood Transfusion

2.0K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
2.0K
Erythropoiesis01:14

Erythropoiesis

5.6K
Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of concurrent pathogen reduction (amotosalen/UVA) and gamma/x-ray irradiation on biochemical characteristics of apheresis platelets in additive solution.

Transfusion·2024
Same author

Granulocyte transfusions in severe aplastic anemia.

Haematologica·2023
Same author

Transfusion of red cells from donors with hereditary haemochromatosis improve haemoglobin increments in patients.

British journal of haematology·2023
Same author

COVID-19 Antibody Detection and Assay Performance Using Red Cell Agglutination.

Microbiology spectrum·2021
Same author

Regulatory challenges of convalescent plasma collection during the evolving stages of COVID-19 pandemic in the United States.

Transfusion·2021
Same author

Naturally Acquired SARS-CoV-2 Immunity Persists for Up to 11 Months Following Infection.

The Journal of infectious diseases·2021

Related Experiment Video

Updated: Jan 1, 2026

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
03:40

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

1.6K

Granulocyte transfusions: Current science and perspectives.

Kamille A West1, Cathy Conry-Cantilena1

  • 1Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, MD.

Seminars in Hematology
|December 15, 2019
PubMed
Summary

Granulocyte transfusions help fight infections in neutropenic patients but their effectiveness remains debated. Current evidence is limited, highlighting the need for further research on granulocyte therapy.

Keywords:
BacteremiaFungemiaGranulocyte transfusionInvasive fungal infectionNeutropeniaNeutrophil dysfunction

More Related Videos

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay
05:52

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

Published on: May 12, 2023

1.7K
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.2K

Related Experiment Videos

Last Updated: Jan 1, 2026

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
03:40

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

1.6K
Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay
05:52

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

Published on: May 12, 2023

1.7K
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.2K

Area of Science:

  • Hematology
  • Infectious Diseases
  • Transfusion Medicine

Background:

  • Severe neutropenia increases susceptibility to life-threatening infections.
  • Granulocyte transfusions have been used since the 1960s to manage infections in neutropenic patients.
  • Despite advancements, the clinical effectiveness of granulocyte transfusion therapy remains controversial and practice varies widely.

Purpose of the Study:

  • To review the current evidence on granulocyte transfusion therapy.
  • To discuss the controversies and persistent concerns surrounding its use.
  • To consider future directions for granulocyte transfusions in neutropenic patients.

Main Methods:

  • Narrative review of existing literature.
  • Summary of current evidence on efficacy and practice variations.
  • Discussion of clinical trial data and expert opinions.

Main Results:

  • Limited and conflicting data exist regarding the clinical effectiveness of granulocyte transfusions.
  • Current clinical trial evidence neither supports nor refutes the efficacy of this therapy.
  • Significant variability in indications, procurement, dosage, and administration protocols is observed globally.

Conclusions:

  • The role and efficacy of granulocyte transfusions in treating or preventing infections in neutropenia require further investigation.
  • Standardization of protocols and robust clinical trials are needed to clarify the benefits of granulocyte therapy.
  • Future research should focus on optimizing patient selection and transfusion strategies.