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Related Concept Videos

Olfaction01:25

Olfaction

47.9K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
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Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
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Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

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Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
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Related Experiment Video

Updated: Jan 1, 2026

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
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Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

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A Nanostructured Microfluidic Artificial Olfaction for Organic Vapors Recognition.

Sajjad Janfaza1,2, Eujin Kim1, Allen O'Brien1

  • 1University of British Columbia, School of Engineering, Kelowna, Canada.

Scientific Reports
|December 15, 2019
PubMed
Summary

This study developed a 3D-printed microfluidic device using polymethyl methacrylate nanoparticles for selective detection of volatile organic compounds (VOCs). The enhanced system shows improved recognition capabilities, particularly for acetone, aiding in chemical monitoring and diagnosis.

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Area of Science:

  • Chemical Sensors
  • Nanotechnology
  • Microfluidics

Background:

  • Selective detection of volatile organic compounds (VOCs) is crucial for hazardous chemical monitoring and non-invasive medical diagnostics.
  • Existing microfluidic olfaction systems often lack the required selectivity for specific VOCs.

Purpose of the Study:

  • To enhance the selectivity of microfluidic gas sensors for VOC detection.
  • To develop a 3D-printed microfluidic platform integrated with functionalized nanoparticles for improved VOC recognition.

Main Methods:

  • Synthesis of polymethyl methacrylate nanoparticles with specific acetone recognition sites.
  • Integration of these nanoparticles into a 3D-printed microfluidic platform with dual parylene C-coated channels.
  • Exposure of the system to various VOCs at different concentrations and analysis of sensor responses using 2D feature extraction.

Main Results:

  • The microfluidic device with polymer nanoparticles demonstrated enhanced recognition capability for VOCs compared to uncoated channels.
  • A significant improvement in acetone recognition was observed, highlighting the effectiveness of the functionalized nanoparticles.
  • The 2D feature extraction method effectively differentiated sensor responses.

Conclusions:

  • The developed 3D-printed microfluidic system, functionalized with polymethyl methacrylate nanoparticles, offers a promising approach to increase and fine-tune the selectivity of microfluidic gas sensors.
  • This technology has potential applications in precise chemical monitoring and advanced diagnostic tools.