Related Experiment Video
Updated: Jan 1, 2026
07:48
Working with Human Tissues for Translational Cancer Research
Published on: November 26, 2015
10.3K
Knowledge Translation in Oncology: The Bumpy Ride From Bench to Bedside
Sarah Morgan1,2, Jessica Hanna1,2, George M Yousef1,2
1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
American Journal of Clinical Pathology
|December 15, 2019
Summary
Knowledge translation (KT) integrates health evidence into patient care. Key challenges include technical limits in genomic testing, provider training, and system accessibility, requiring patient, professional, and system-level strategies.
Area of Science:
- Health services research
- Translational science
- Genomic medicine implementation
Background:
- Knowledge translation (KT) is crucial for evidence-based healthcare decisions.
- Integrating scientific discoveries into clinical practice faces significant hurdles.
Purpose of the Study:
- To identify challenges and define milestones in knowledge translation for healthcare.
- To outline strategies for effective implementation of research evidence.
Main Methods:
- A PubMed search was conducted to identify challenges in knowledge translation.
- Milestones for knowledge translation were defined based on identified challenges.
Main Results:
- Genomic testing presents technical challenges: turnaround time, standardization, reproducibility, and interpretation.
- Barriers include inadequate provider training in genetic counseling, unclear evidence, and ethical/legal/social issues.
- Healthcare systems often lack accessible genetic testing services.
Conclusions:
- Knowledge translation requires a multi-frontier approach: patient-centered, professional-focused, and system-resourced.
- Successful KT implementation necessitates strategies for awareness, behavioral change, and systematic approaches for patient-centered care.
Related Concept Videos
02:50Combination Therapies and Personalized Medicine
5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
02:57Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
02:18Cancer
53.3K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.3K
02:49Cancer Therapies
9.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
01:21Cancer Survival Analysis
609
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
609
02:56Treatment Resistant Cancers
3.6K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.6K