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Updated: Jan 1, 2026

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
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Progress toward liquid biopsies in pediatric solid tumors.

Daniel A Weiser1, Diana C West-Szymanski2, Ellen Fraint1

  • 1Department of Pediatrics, Albert Einstein College of Medicine and Children's Hospital at Montefiore, Bronx, NY, USA.

Cancer Metastasis Reviews
|December 15, 2019
PubMed
Summary
This summary is machine-generated.

Liquid biopsies offer minimally invasive tools for pediatric cancer care. These advanced assays analyze circulating tumor materials to improve diagnosis, prognosis, and personalized treatment strategies for childhood solid tumors.

Keywords:
Cell-free DNAEpigeneticsLiquid biopsyNext-generation sequencingPediatric solid tumors

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Pediatric solid tumors release detectable materials like DNA and RNA into circulation.
  • Technological advancements enhance the capture and analysis of these scarce circulating tumor biomarkers.
  • Liquid biopsies are being developed as minimally invasive tools for childhood cancer management.

Purpose of the Study:

  • To review the latest technologies for liquid biopsies in pediatric oncology.
  • To discuss the methods, challenges, and advantages of these assays for extracranial solid tumors in children.
  • To highlight advancements in understanding tumor biology and personalized therapy through serial liquid biopsies.

Main Methods:

  • Review of current technologies for detecting circulating tumor DNA (ctDNA), RNA, and proteins.
  • Analysis of assay performance, including sensitivity and specificity for pediatric cancers.
  • Examination of clinical applications in diagnosis, prognosis, and monitoring of neuroblastoma, sarcoma, Wilms tumor, and hepatoblastoma.

Main Results:

  • Liquid biopsy technologies show promise for non-invasive cancer detection and monitoring in children.
  • Serial liquid biopsies provide insights into tumor heterogeneity and evolution during treatment.
  • Successful application in common pediatric solid tumors like neuroblastoma and sarcoma is demonstrated.

Conclusions:

  • Liquid biopsies represent a significant advancement in pediatric cancer diagnostics and personalized medicine.
  • Further research and clinical validation are crucial for widespread adoption in childhood cancer care.
  • Serial liquid biopsies will likely transform the management of pediatric solid tumors.