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Published on: February 9, 2022
Effect of vitamin D on lung function assessed by forced oscillation technique in asthmatic children with vitamin D
Napatsayod Swangtrakul1, Wiparat Manuyakorn1, Pat Mahachoklertwattana1
1Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Insights
Vitamin D treatment did not improve lung function in vitamin D deficient children with asthma. Further research is needed to determine the long-term effects of vitamin D supplementation in asthmatic patients.
Area of Science:
- Pediatric Pulmonology
- Nutritional Immunology
- Respiratory Medicine
Background:
- Conflicting results exist regarding the impact of vitamin D on asthma and pulmonary function.
- Asthma management often involves addressing potential nutritional deficiencies.
- Vitamin D's role in respiratory health is an area of ongoing investigation.
Purpose of the Study:
- To investigate the effect of vitamin D treatment on lung function in vitamin D-deficient asthmatic children.
- To assess changes in pulmonary function using the forced oscillation technique (FOT).
- To evaluate short-term benefits of vitamin D supplementation in this population.
Main Methods:
- A randomized, double-blind, placebo-controlled trial involving 84 children (aged 3-18) with well-controlled asthma.
- Participants were categorized into non-vitamin D deficient (nVDD), vitamin D2 treated deficient (tVDD), and placebo deficient (pVDD) groups.
- Forced oscillation technique (FOT) parameters and serum 25(OH)D levels were measured at baseline, 1 month, and 3 months.
Main Results:
- No significant differences in FOT parameters were observed between the vitamin D treatment and placebo groups.
- A trend towards decreased respiratory resistance (R5/R20) was noted in all groups, with significant improvement only in the nVDD group.
- Serum 25(OH)D levels did not correlate with FOT measures.
Conclusions:
- Vitamin D treatment showed no short-term beneficial effect on pulmonary function in vitamin D-deficient asthmatic children.
- The findings suggest that vitamin D supplementation may not acutely improve lung function in this group.
- Further studies are warranted to explore the long-term effects and broader implications of vitamin D supplementation in asthma.
Background:
The role of vitamin D and asthma in pulmonary function changes showed conflicting result.
Objective:
To evaluate if vitamin D treatment would improve lung function assessed by forced oscillation technique (FOT) in vitamin D deficient asthmatic children.
Methods:
A randomized double-blind placebo-controlled trial was performed in children, aged 3-18 years with well controlled asthma. Serum total 25(OH)D and FOT parameters including respiratory resistance at 5 Hz (R5), at 20 Hz (R20), respiratory reactance at 5 Hz (X5) and area of reactance (ALX), resonance frequency (Fres) were evaluated at baseline, 1 month and 3 months. Vitamin D deficient patients (serum total 25(OH)D < 20 ng/ml) were randomized to receive treatment with vitamin D2 (tVDD) or placebo (pVDD). Non-vitamin D deficient patients (nVDD) received placebo as a control group.
Results:
A total of 84 children were recruited, 43 patients in nVDD group, 20 in tVDD group and 21 in pVDD group. There were no significant differences in age, sex, height and weight among groups. There were no significant differences of FOT parameters among groups at all visits. There was a trend toward decrease in R5/R20 from baseline to 1 month and 3 months visit in all groups, but the statistically significant improvement was observed only in nVDD group. Serum 25(OH)D showed no correlation with % predicted of FOT measures.
Conclusions:
Vitamin D treatment in asthmatic children who had vitamin D deficiency may have no short term beneficial effect on pulmonary function assessed by FOT. Vitamin D supplementation in all asthmatic patient needs further study.
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