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Age-related changes in microbial composition and function in cynomolgus macaques.

Jiajia Duan1,2, Bangmin Yin1,3, Wei Li4

  • 1NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, Chongqing Medical University, Chongqing, China.

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|December 15, 2019
PubMed
Summary

Aging alters the gut microbiota composition and function. This study in macaques reveals age-related shifts in specific bacterial families and metabolic pathways, offering insights into gut microbiome changes with age.

Keywords:
agecynomolgus macaquesgut microbiotametagenomics

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Area of Science:

  • Microbiome research
  • Aging and health
  • Primate models

Background:

  • Age significantly impacts human physiology and disease susceptibility.
  • Gut microbiota composition and function are known to change with age, but mechanisms are unclear.
  • Non-human primates offer a valuable model due to gut microbial similarity to humans.

Purpose of the Study:

  • To characterize age-related changes in gut microbial phenotypes.
  • To investigate the functional implications of these microbial shifts.
  • To establish a foundation for understanding aging's effects on the human gut.

Main Methods:

  • 16S rRNA sequencing for microbial composition analysis.
  • Metagenomic sequencing for functional profiling.
  • Comparative analysis across three age groups (young, adult, old) of cynomolgus macaques.

Main Results:

  • Significant differences in gut microbial composition were observed across age groups.
  • Specific bacterial families like *Veillonellaceae* and *Coriobacteriaceae* increased with age, while *Ruminococcaceae* decreased.
  • Differentially abundant genes were linked to arginine biosynthesis, purine metabolism, and polysaccharide metabolism.

Conclusions:

  • Gut microbiota composition and function demonstrably change with age in cynomolgus macaques.
  • Age-associated microbial shifts involve alterations in key metabolic pathways.
  • These findings provide a novel perspective on the impact of aging on the gut microbiome.