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Long non-coding RNA LOC285194 in cancer
Lingli Luo1, Min Wang1, Xianping Li1
1Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 15, 2019
Summary
Long non-coding RNAs (lncRNAs) like LOC285194 are crucial in cancer. This review highlights LOC285194
Area of Science:
- Molecular Biology
- Genomics
- Cancer Research
Background:
- Long non-coding RNAs (lncRNAs) are key regulators in biological processes.
- Whole-genome sequencing aids in identifying lncRNAs and their roles in human cancers.
- LOC285194 (TUSC7) is a lncRNA frequently downregulated in tumors, correlating with poor prognosis.
Purpose of the Study:
- To review and synthesize current literature on the functions and mechanisms of LOC285194 in human cancers.
- To explore LOC285194's potential as a cancer biomarker and therapeutic target.
Main Methods:
- Literature review and synthesis of existing research on LOC285194.
- Analysis of studies investigating LOC285194 expression, function, and clinical relevance in various cancers.
Main Results:
- LOC285194 expression is consistently low in tumor cells and linked to adverse clinical outcomes.
- Overexpression of LOC285194 inhibits cancer cell proliferation, invasion, and migration in vitro and in vivo.
- LOC285194 influences cancer-related gene expression through direct and indirect mechanisms.
Conclusions:
- LOC285194 plays a significant role in suppressing tumor progression.
- LOC285194 holds promise as a potential diagnostic biomarker and therapeutic target for human cancers.
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