Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

140
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
140
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

375
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
375
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

319
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
319
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

321
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
321
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

222
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
222
Renal Regulation of Acid-Base Balance01:29

Renal Regulation of Acid-Base Balance

1.4K
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glycoproteomic and genetic analysis of N-glycosylation of complement component C3 reveals immune pathway regulation.

Genome biology·2026
Same author

LiRNA: An Interactive Atlas of Human Liver RNAseq Databases.

JHEP reports : innovation in hepatology·2026
Same author

Flow-enhanced electrochemical aptamer sensor for nanomolar detection of NGAL in blood plasma for kidney injury diagnosis.

Biosensors & bioelectronics·2026
Same author

TGFβ activity stabilizes ACC1 to increase de novo lipogenesis in metabolic liver disease.

Molecular metabolism·2026
Same author

Autologous macrophage therapy increases transplant-free survival in cirrhosis: Long-term follow-up of a phase 2 clinical trial.

Cell stem cell·2026
Same author

Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome.

Cell·2026

Related Experiment Video

Updated: Jan 1, 2026

Transcutaneous Assessment of Renal Function in Conscious Rodents
07:18

Transcutaneous Assessment of Renal Function in Conscious Rodents

Published on: March 26, 2016

12.9K

Coffee Consumption and Kidney Function: A Mendelian Randomization Study.

Oliver J Kennedy1, Nicola Pirastu2, Robin Poole1

  • 1Primary Care & Population Sciences Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|December 16, 2019
PubMed
Summary
This summary is machine-generated.

Drinking coffee may protect kidney function. This study found that daily coffee consumption is associated with a reduced risk of chronic kidney disease (CKD) and albuminuria, and higher estimated glomerular filtration rate (eGFR).

Keywords:
Mendelian randomisationalbuminuriachronic kidney disease (CKD)coffeedietary habitseGFR (estimated glomerular filtration rate)genetic analysisgenetic epidemiologygenome-wide association study (GWAS)modifiable risk factorrenal functionsingle nucleotide polymorphism (SNP)

More Related Videos

Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.4K
Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method
08:15

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Published on: May 22, 2019

10.6K

Related Experiment Videos

Last Updated: Jan 1, 2026

Transcutaneous Assessment of Renal Function in Conscious Rodents
07:18

Transcutaneous Assessment of Renal Function in Conscious Rodents

Published on: March 26, 2016

12.9K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.4K
Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method
08:15

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Published on: May 22, 2019

10.6K

Area of Science:

  • Nephrology
  • Nutritional Epidemiology
  • Genetics

Background:

  • Chronic kidney disease (CKD) is a major global health concern with limited preventive strategies.
  • Coffee consumption is widespread and linked to various health benefits.
  • Understanding coffee's impact on kidney function is crucial for public health.

Purpose of the Study:

  • To investigate the association between coffee consumption and kidney function.
  • To determine if genetic factors influence coffee's effect on kidney health.

Main Methods:

  • Utilized genome-wide association study (GWAS) on UK Biobank data (227,666 participants) for coffee consumption.
  • Employed Mendelian randomization with CKDGen Consortium data (133,814 participants) for kidney outcomes.
  • Analyzed associations with estimated glomerular filtration rate (eGFR), CKD stages G3-G5, and albuminuria.

Main Results:

  • Identified 2,126 single-nucleotide polymorphisms (SNPs) associated with coffee consumption.
  • Found that each daily cup of coffee was linked to a protective effect against CKD G3-G5 (OR=0.84) and albuminuria (OR=0.81).
  • Observed a significant association between higher eGFR and coffee consumption (β=0.022).

Conclusions:

  • Coffee consumption demonstrates a beneficial impact on kidney function.
  • Findings suggest potential public health implications for CKD prevention given widespread coffee intake.
  • Further research may explore mechanisms behind coffee's renal protective effects.