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Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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Targeting SHP2 as a promising strategy for cancer immunotherapy

Qianqian Liu1, Jiao Qu1, Mingxia Zhao1

  • 1State Key Laboratory of Pharmaceutical Biotechnology, Department of Biotechnology and Pharmaceutical Sciences, School of Life Science, Nanjing University, 163 Xianlin Avenue, Nanjing, 210023, China.

Pharmacological Research
|December 16, 2019
PubMed

Insights

Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) is crucial in cancer and immune responses. SHP2 inhibitors show promise as a cancer immunotherapy strategy.

Area of Science:

  • Biochemistry
  • Immunology
  • Oncology

Background:

  • Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) is a key phosphatase regulating cellular functions.
  • SHP2 is increasingly recognized for its role in human diseases, especially cancer.
  • SHP2 influences immune cell activity within the tumor microenvironment.

Purpose of the Study:

  • To review the regulation of SHP2.
  • To highlight SHP2's roles in T lymphocytes, macrophages, and cancer cells.
  • To summarize the development of SHP2 inhibitors for cancer immunotherapy.

Main Methods:

  • Literature review of SHP2 regulation.
  • Analysis of SHP2 function in immune cells and cancer.
  • Summary of clinical trial data for SHP2 inhibitors.

Main Results:

  • SHP2 plays a vital role in T lymphocytes, macrophages, and cancer cells.
  • SHP2 allosteric inhibitors have demonstrated significant anti-tumor effects in clinical trials.
  • SHP2 inhibitors exhibit favorable safety profiles.

Conclusions:

  • SHP2 is a critical target for cancer therapy.
  • SHP2 inhibitors represent a promising avenue for cancer immunotherapy development.
Keywords:
MacrophageSHP2SHP2 inhibitorT lymphocyteTumor immunotherapy

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