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Related Experiment Video

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Paired Cisterna Magna Nanoinjection and Laser Speckle Contrast Imaging Assay to Study Cerebral Blood Flow Regulation In Vivo

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Methods to measure, model and manipulate fluid flow in brain.

Krishnashis Chatterjee¹, Cora M Carman-Esparza¹, Jennifer M Munson¹

¹Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences, Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.

Journal of Neuroscience Methods

|December 16, 2019

Summary

Studying brain fluid dynamics is crucial for understanding neurological diseases like Alzheimer's. This review covers methods to investigate cerebrospinal fluid, blood, and interstitial fluid movement and their impact on neural function.

Keywords:

Cerebrospinal fluid Computational modeling Glymphatic In vitro models Interstitial flow Lymphatics MRI

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Area of Science:

Neuroscience
Biophysics

Background:

The brain relies on intricate fluid systems (cerebrospinal, blood, interstitial) for cushioning and nourishment.
Disruptions in brain fluid flow are implicated in diseases such as Alzheimer's Disease and glioblastoma.

Purpose of the Study:

To review current methodologies for studying brain fluid dynamics.
To explore the role of fluid flow in neural function and disease.

Main Methods:

Magnetic resonance imaging (MRI) for in vivo and pre-clinical flow imaging.
Computational and in vitro modeling to parameterize and validate fluid flow.
In vivo manipulation techniques (physical, pharmacological) to determine causal relationships.

Main Results:

Imaging and modeling approaches elucidate disease-related changes in brain fluid flow.
In vitro models allow cellular response studies under physiological flow conditions.
In vivo manipulations yield significant preclinical findings regarding flow and neural function.

Conclusions:

Investigating brain fluid dynamics, including the glymphatic system, is a rapidly advancing research area.
Understanding fluid flow is essential for determining its impact on neural function and disease pathology.