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Updated: Jan 1, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Organocatalytic Combinatorial Synthesis of Quinazoline, Quinoxaline and Bis(indolyl)methanes
Fatemeh Malamiri1, Samad Khaksar2,3, Rashid Badri4
1Department of Chemistry, Khouzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran.
Aims And Objective:
An efficient and practical procedure for the synthesis of heterocyclic compounds such as quinazolines, quinoxalines and bis(indolyl)methanes was developed using 3,5-bis(trifluoromethyl) phenyl ammonium hexafluorophosphate (BFPHP) as a novel organocatalyst.
Materials And Methods:
All of the obtained products are known compounds and identified by IR, 1HNMR, 13CNMR and melting points.
Result:
Various products were obtained in good to excellent yields under reaction conditions.
Conclusion:
The BFPHP organocatalyst demonstrates a novel class of non-asymmetric organocatalysts, which has gained much attention in green chemistry.
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