Individualised target volume selection and dose prescription after conservative surgery, mastectomy and...

Progress in radiotherapy (RT) for early breast cancer, driven by advances in radiobiology and radiation techniques is enabling individualised target volume and dose-fractionation according to recurrence risk. Conventionally fractionated WBI (CF-WBI) has been justified on the basis that it spares dose-limiting late-responding normal tissues more than breast cancer. However, randomised clinical trials (RCTs) testing hypofractionated WBI (HF-WBI) showed equivalent tumour control, improved acute toxicity and similar late toxicity between selected HF-WBI schedules and CF-WBI. RCTs showed that tumour bed boost (TBB) after WBI improved local control but increased breast fibrosis compared to no TBB. RCT comparing sequential TBB and simultaneous integrated TBB using dose intensity modulation showed similar toxicity. Partial breast irradiation (PBI) limits target volume to the tumour bed, which permits safe treatment acceleration. RCTs showed that PBI resulted in low local relapse rates but in some RCTs, higher rates of late toxicity and adverse cosmetic outcome than WBI. Given heterogeneity of PBI techniques, target volumes and dose-fractionation schedules used in RCTs, interpretation of results to distinguish whether outcome variations are caused by target volume or dose-fractionation effect is challenging. RCTs demonstrating efficacy of post-mastectomy RT (PMRT) included the chest wall and regional nodes but did not distinguish relative contributions of nodal target sub-volumes. In patients with smaller axillary tumour burden, IMC irradiation is controversial. RCTs were not powered for comparison between CF-PMRT and HF-PMRT. No increase in arm or shoulder dysfunction with HF-PMRT was observed. No RCT data exist on HF-PMRT in patients with breast reconstruction.