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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
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Reticular Dermis01:15

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Jan 1, 2026

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[Pseudoxanthoma elasticum-like papillary dermal elastolysis: A case report].

C Jacquin-Porretaz1, F Aubin1, F Vibratte2

  • 1Service de dermatologie, CHRU Besançon, 3, boulevard Alexandre-Fleming, 25000 Besançon, France.

Annales De Dermatologie Et De Venereologie
|December 17, 2019
PubMed
Summary

Pseudoxanthoma elasticum-like papillary dermal elastolysis (PXE-PDE) is a rare skin condition affecting older women. This report details a typical case, highlighting its distinct clinical and histological features for accurate diagnosis.

Keywords:
Derme papillaireElastolysisElastorrhexisPapillary dermisPseudoxanthoma elasticumPseudoxanthome élastiqueÉlastolyseÉlastorrhexie

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Area of Science:

  • Dermatology
  • Pathology
  • Rare Diseases

Background:

  • Pseudoxanthoma elasticum-like papillary dermal elastolysis (PXE-PDE) is a rare condition.
  • It clinically resembles pseudoxanthoma elasticum (PXE).

Observation:

  • A 77-year-old woman presented with a 4-year history of asymptomatic papular eruption.
  • The eruption was located on the axillae, chest, neck, and inguinal fold.
  • Histology revealed papillary and mid-dermal elastolysis without elastorrhexis.

Findings:

  • PXE-PDE is an acquired condition typically affecting women over 60.
  • It is differentiated from PXE by late onset, lack of systemic symptoms, and specific histological findings.
  • Histological examination shows reduced or absent elastic fibers in the papillary and mid-dermis.

Implications:

  • Accurate diagnosis of PXE-PDE avoids unnecessary investigations.
  • Understanding PXE-PDE aids in patient reassurance.
  • Potential physiopathology may involve skin aging, elastogenesis, and UV exposure.