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Updated: Jan 1, 2026

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
[Spontaneous regression of primary gastric EBV-positive diffuse large B-cell lymphoma]
Mayumi Hatsuse1, Daisuke Ide1, Saori Matsui1
1Department of Hematology, Japan Community Health care Organization, Kyoto Kuramaguchi Medical Center.
Abstract:
Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) in the elderly was revised from the category EBV-positive DLBCL not otherwise specified in WHO 2017. The prognosis of this lymphoma is very poor. We report a case of an 82-year-old woman diagnosed with gastric EBV-positive DLBCL (WHO 2008). Gastroduodenoscopy revealed multiple ulcers and fold thickening. She was followed-up without any treatment because of her old age. Repeat endoscopy one year and eight months later revealed a single ulcer with no lymphoma cells found in a biopsy specimen. Two years later, the lesion had spontaneously disappeared.
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